News Patologia clinica

Journal of Biological Rhythms, Ahead of Print. Circadian clocks regulate multiple physiological processes in the eye, but their requirement for retinal health remains unclear. We previously showed that Drosophila homologs of spliceosome proteins implicated in human retinitis pigmentosa (RP), the most common genetically inherited cause of blindness, have a role... Leggi di più
Pubblicato il 15-11-2019
Fonte: JOURNAL OF BIOLOGICAL RHYTHMS - online first articles
By Iryna Shakhmantsir
Journal of Biological Rhythms, Ahead of Print. The suprachiasmatic nucleus (SCN) is the main brain clock in mammals. The SCN synchronizes to the light-dark cycle through the retinohypothalamic tract (RHT). RHT axons release glutamate to activate AMPA-kainate and N-methyl-D-aspartate (NMDA) postsynaptic receptors in ventral SCN neurons. Stimulation of SCN NMDA... Leggi di più
Pubblicato il 15-11-2019
Fonte: JOURNAL OF BIOLOGICAL RHYTHMS - online first articles
By Miriam E. Reyes-Mendez
Journal of Biological Rhythms, Ahead of Print. The suprachiasmatic nucleus (SCN) is the main brain clock in mammals. The SCN synchronizes to the light-dark cycle through the retinohypothalamic tract (RHT). RHT axons release glutamate to activate AMPA-kainate and N-methyl-D-aspartate (NMDA) postsynaptic receptors in ventral SCN neurons. Stimulation of SCN NMDA... Leggi di più
Pubblicato il 15-11-2019
Fonte: JOURNAL OF BIOLOGICAL RHYTHMS - recent articles
By Miriam E. Reyes-Mendez
Enterovirus D68 (EV-D68) causes respiratory illnesses such as pneumonia, and has been reported to cause acute flaccid myelitis. Enterovirus A71 (EV-A71) is known to cause cardiopulmonary failure due to brainstem encephalitis, but there have been few reports of these conditions being associated with EV-D68. Outbreaks of EV-D68 infection have occurred... Leggi di più
Pubblicato il 15-11-2019
Fonte: BMJ CASE REPORTS - recent articles
By Yogo, N., Imamura, T., Muto, Y., Hirai, K.
We can conclude that no co-trimoxazole is not inferior to daily co-trimoxazole among breastfed HIV-exposed, HIV-uninfected infants whose mothers are accessing a prevention of mother-to-child transmission programme in an area unaffected by malaria. We therefore believe that WHO should revise the co-trimoxazole guidelines for HIV-exposed, HIV-uninfected infants in areas unaffected... Leggi di più
Pubblicato il 14-11-2019
Fonte: THE LANCET INFECTIUOS DISEASES - collections: hiv/aids
By Brodie Daniels, Anna Coutsoudis, Eshia Moodley-Govender, Helen Mulol, Elizabeth Spooner, Photini Kiepiela, Shabashini Reddy, Linda Zako, Nhan T Ho, Louise Kuhn, Gita Ramjee
Routine antenatal care-based screening can be used to assess heterogeneity in transmission at finer resolution than population-based surveys, and provides sample sizes powered to detect changes, notably in areas of low transmission where surveys lack power. Declines in prevalence at antenatal care might lag behind those among children, highlighting the... Leggi di più
Pubblicato il 14-11-2019
Fonte: THE LANCET INFECTIUOS DISEASES - collections: malaria
By Chonge Kitojo, Julie R Gutman, Frank Chacky, Emmanuel Kigadye, Sigsbert Mkude, Renata Mandike, Ally Mohamed, Erik J Reaves, Patrick Walker, Deus S Ishengoma
No abstract available... Leggi di più
Pubblicato il 14-11-2019
Fonte: CURRENT OPINION IN ORGAN TRANSPLANTATION - most viewed articles
The Andrew Herxheimer memorial lecture at the 2019 Paris general assembly of the International Society of Drug Bulletins, delivered by Alan Cassels (Communications Director, Therapeutics Initiative, University of British Columbia) and Dee Mangin (Professor of Family Medicine at McMaster University), focused on the burden of overprescribing. Both speakers provided a... Leggi di più
Pubblicato il 14-11-2019
Fonte: DRUG AND THERAPEUTIC BULLETIN - online first
By Cave, J. A.
Vascular invasion has been identified as an informative risk factor for relapse in stage I testicular nonseminomas, used to tailor treatment. We investigated interobserver agreement in vascular invasion reporting and studied the potential additional value of immunohistochemistry for vascular markers for predicting relapse. Patients (n=52) with stage I testicular nonseminomas... Leggi di più
Pubblicato il 14-11-2019
Fonte: THE AMERICAN JOURNAL OF SURGICAL PATHOLOGY - most viewed articles
Introduction Severe acute malnutrition (SAM) in children in many countries still carries unacceptably high mortality, especially when complicated by secondary infection or metabolic derangements. New therapies are urgently needed and we have identified mucosal healing in the intestine as a potential target for novel treatment approaches. Methods and analysis The... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Kelly, P., Bell, L., Amadi, B., Bwakura-Dangarembizi, M., VanBuskirk, K., Chandwe, K., Chipunza, M., Ngosa, D., Chulu, N., Hill, S., Murch, S., Playford, R., Prendergast, A.
Introduction Two of the most acute and feared complications in type 1 diabetes (T1D) are hypoglycaemia and severe hypoglycaemia (SH). While impaired awareness of hypoglycaemia (IAH) can lead to SH with cognitive and motivational barriers implicated, the available education does not integrate behavioural change techniques to address these. A novel... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Soukup, T., Hull, L., Smith, E. L., Healey, A., Bakolis, I., Amiel, S. A., Sevdalis, N., Group, P.
Objectives Premedication practices for neonatal tracheal intubations have not yet been described for neonatal transport teams. Our objective is to describe the use of sedation/analgesia (SA) for tracheal intubations and to assess its tolerance in neonates transported by medical transport teams in France. Setting This prospective observational study was part... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Carbajal, R., Lode, N., Ayachi, A., Chouakri, O., Henry-Larzul, V., Kessous, K., Normand, A., Courtois, E., Rousseau, J., Cimerman, P., Chabernaud, J.-L.
Background Septic shock is a life-threatening infection frequently responsible for hospital admissions or may be acquired as nosocomial infection in hospitalized patients with resultant significant morbidity and mortality . There is a dearth of data on a résumé and meta-analysis on the global epidemiology of this potentially deadly condition. Therefore,... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Tianyi, F. L., Tochie, J. N., Danwang, C., Mbonda, A., Temgoua, M. N., Mapoh, S. Y., Nkemngu, N. J., Tallah, E., Bigna, J. J.
Objective Low neighbourhood socioeconomic status (NSES) has been linked to a higher risk of overweight/obesity, irrespective of the individual’s own socioeconomic status. No meta-analysis study has been done on the association. Thus, this study was done to synthesise the existing evidence on the association of NSES with overweight, obesity and... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Mohammed, S. H., Habtewold, T. D., Birhanu, M. M., Sissay, T. A., Tegegne, B. S., Abuzerr, S., Esmaillzadeh, A.
Introduction Selective reporting bias, inconsistency in the chosen outcomes between trials and irrelevance of the chosen outcomes for women, limit the efficiency and value of research for prevention and treatment of gestational diabetes mellitus (GDM). One way to address these challenges is to develop core outcome sets (COSs). Methods and... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Egan, A. M., Dunne, F. P., Biesty, L. M., Bogdanet, D., Crowther, C., Dempsey, E., Thangaratinam, S., Devane, D., Fhelelboom, N., On behalf of the INSPIRED (INternational collaboration for Studies in PREgnacy and Diabetes) research group.
Introduction Depression represents a major public health concern for children and adolescents, and is thought to negatively impact subsequent educational attainment. However, the extent to which depression and educational attainment are directly associated, and whether other factors play a role, is uncertain. Therefore, we aim to systematically review the literature... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Wickersham, A., Epstein, S., Sugg, H. V. R., Stewart, R., Ford, T., Downs, J.