News Ematologia

Toll-like receptors are transmembrane proteins which sense and transmit infectious and inflammatory responses to the cells expressing them. Therapeutic strategies for the blockade of excessive Toll-like receptor signaling are being actively pursued for several diseases. Recently, Sparstolonin B, isolated from Chinese herb, which suppresses selectively Toll-like receptors has been studied... Leggi di più
Pubblicato il 15-11-2019
Fonte: SHOCK - most viewed articles
Therapeutic Advances in Hematology, Volume 10, Issue , January-December 2019. High-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) has historically been an essential part of multiple myeloma (MM) management since early studies demonstrated its efficacy in relapsed disease, and subsequent phase III trials demonstrated better responses and improved survival with... Leggi di più
Pubblicato il 15-11-2019
Fonte: THERAPEUTIC ADVANCES IN HEMATOLOGY - recent articles
By Cinnie Y. Soekojo
Enterovirus D68 (EV-D68) causes respiratory illnesses such as pneumonia, and has been reported to cause acute flaccid myelitis. Enterovirus A71 (EV-A71) is known to cause cardiopulmonary failure due to brainstem encephalitis, but there have been few reports of these conditions being associated with EV-D68. Outbreaks of EV-D68 infection have occurred... Leggi di più
Pubblicato il 15-11-2019
Fonte: BMJ CASE REPORTS - recent articles
By Yogo, N., Imamura, T., Muto, Y., Hirai, K.
The addition of isatuximab to pomalidomide–dexamethasone significantly improves progression-free survival in patients with relapsed and refractory multiple myeloma. Isatuximab is an important new treatment option for the management of relapsed and refractory myeloma, particularly for patients who become refractory to lenalidomide and a proteasome inhibitor.... Leggi di più
Pubblicato il 15-11-2019
Fonte: THE LANCET HAEMATOLOGY - collections
By Michel Attal, Paul G Richardson, S Vincent Rajkumar, Jesus San-Miguel, Meral Beksac, Ivan Spicka, Xavier Leleu, Fredrik Schjesvold, Philippe Moreau, Meletios A Dimopoulos, Jeffrey Shang-Yi Huang, Jiri Minarik, Michele Cavo, H Miles Prince, Sandrine Macé, Kathryn P Corzo, Frank Campana, Solenn Le-Guennec, Franck Dubin, Kenneth C Anderson, ICARIA-MM study group
No abstract available... Leggi di più
Pubblicato il 14-11-2019
Fonte: CURRENT OPINION IN ORGAN TRANSPLANTATION - most viewed articles
The Andrew Herxheimer memorial lecture at the 2019 Paris general assembly of the International Society of Drug Bulletins, delivered by Alan Cassels (Communications Director, Therapeutics Initiative, University of British Columbia) and Dee Mangin (Professor of Family Medicine at McMaster University), focused on the burden of overprescribing. Both speakers provided a... Leggi di più
Pubblicato il 14-11-2019
Fonte: DRUG AND THERAPEUTIC BULLETIN - online first
By Cave, J. A.
Objectives Greenspace is one of the important factors that can promote an active lifestyle. Thus, greener surroundings may be a motivating factor for people with newly diagnosed diabetes to engage in more physical activity. Given that diagnosis of type 2 diabetes (T2D) may serve as a window opportunity for behavioural... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Chong, S., Mazumdar, S., Ding, D., Morgan, G., Comino, E. J., Bauman, A., Jalaludin, B.
Objectives The diagnosis and treatment of acute leukaemia (AL) affect physical, psychosocial and existential functioning. Long-lasting treatment periods with impaired immune system, hygienic and social restrictions challenge patient well-being and rehabilitation as compared with other individuals with cancer. This study elucidates how AL patients, treated with curative intent in an... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Jepsen, L. O., Friis, L. S., Hoybye, M. T., Marcher, C. W., Hansen, D. G.
Objective To identify the core components of successful early warning systems for detecting and initiating action in response to clinical deterioration in paediatric inpatients. Methods A hermeneutic systematic literature review informed by translational mobilisation theory and normalisation process theory was used to synthesise 82 studies of paediatric and adult early... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Jacob, N., Moriarty, Y., Lloyd, A., Mann, M., Tume, L. N., Sefton, G., Powell, C., Roland, D., Trubey, R., Hood, K., Allen, D.
Objective ‘Core information sets’ (CISs) represent baseline information, agreed by patients and professionals, to stimulate individualised patient-centred discussions. This study developed a CIS for use before colorectal cancer (CRC) surgery. Design Three phase consensus study: (1) Systematic literature reviews and patient interviews to identify potential information of importance to patients,... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By McNair, A. G. K., Whistance, R. N., Main, B., Forsythe, R., Macefield, R., Rees, J., Pullyblank, A., Avery, K., Brookes, S., Thomas, M. G., Sylvester, P. A., Russell, A., Oliver, A., Morton, D., Kennedy, R., Jayne, D., Huxtable, R., Hackett, R., Dutton, S., Coleman, M. G., Card, M., Brown, J., Blazeby, J.
Objectives We aimed to analyse the healthcare seeking behaviours (HSB) of populations with different migration status and examine the relationship between migration status and HSB. Design A secondary analysis of cross-sectional data of China Labor-force Dynamics Survey wave 2016, which was conducted by the Sun Yat-sen University every 2 years... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Peng, B., Zhang, H., Shi, L., Ling, L.
Introduction Patient-centred infertility care (PCIC) is one of the quality indicators of effective fertility care. The application of this indicator requires a clear definition from the patient’s perspective. This proposed scoping review aims to explore the extent and nature of published scientific literature on PCIC in the past decade, identify... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Webair, H. H., Ismail, T. A. T., Ismail, S. B., Mohd Noor, N.
Introduction Worldwide, 2 million patients aged 18–50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provision of... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Ekker, M., Jacob, M., van Dongen, M., Aarnio, K., Annamalai, A., Arauz, A., Arnold, M., Barboza, M., Bolognese, M., Brouns, R., Chuluun, B., Chuluunbaatar, E., Dagvajantsan, B., Debette, S., Don, A., Enzinger, C., Ekizoglu, E., Fandler-Höfler, S., Fazekas, F., Fromm, A., Gattringer, T., Gulli, G., Hoffmann, M., Hora, T., Jern, C., Jood, K., Kamouchi, M., Kim, Y. S., Kitazono, T., Kittner, S., Kleinig, T., Klijn, K., Korv, J., Lee, T.-H., Leys, D., Maaijwee, N., Martinez-Majander, N., Marto, J. P., Mehndiratta, M., Mifsud, V., Montanaro, V., Owolabi, M. O., Patel, V., Phillips, M., Piechowski-Iozwiak, B., Pikula, A., Ruiz-Sandoval, J. L., Sarnowski, B., Schreuder, F., Swartz, R., Tan, K., Tanne, D., Tatlisumak, T., Thijs, V., Tuladhar, A., Viana-Baptista, M., Vibo, R., Wu, T., Yesilot, N., Waje-Andreassen, U., Pezzini, A., Putaala, J., de Leeuw, F.-E.
Objectives This study aimed to assess the degree to which the ‘social cure’ model of psychosocial health captures the understandings and experiences of healthcare staff and patients in a social prescribing (SP) pathway and the degree to which these psychosocial processes predict the effect of the pathway on healthcare usage.... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Kellezi, B., Wakefield, J. R. H., Stevenson, C., McNamara, N., Mair, E., Bowe, M., Wilson, I., Halder, M. M.
Introduction Severe acute malnutrition (SAM) in children in many countries still carries unacceptably high mortality, especially when complicated by secondary infection or metabolic derangements. New therapies are urgently needed and we have identified mucosal healing in the intestine as a potential target for novel treatment approaches. Methods and analysis The... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Kelly, P., Bell, L., Amadi, B., Bwakura-Dangarembizi, M., VanBuskirk, K., Chandwe, K., Chipunza, M., Ngosa, D., Chulu, N., Hill, S., Murch, S., Playford, R., Prendergast, A.
Introduction Two of the most acute and feared complications in type 1 diabetes (T1D) are hypoglycaemia and severe hypoglycaemia (SH). While impaired awareness of hypoglycaemia (IAH) can lead to SH with cognitive and motivational barriers implicated, the available education does not integrate behavioural change techniques to address these. A novel... Leggi di più
Pubblicato il 14-11-2019
Fonte: BMJ OPEN - current issue only
By Soukup, T., Hull, L., Smith, E. L., Healey, A., Bakolis, I., Amiel, S. A., Sevdalis, N., Group, P.