News Malattie Infettive

Purpose of review describing the current role of carbapenems and carbapenem-sparing strategies in the setting of antimicrobial stewardship programs. Recent findings sparing carbapenems with other drugs appears to be an interesting perspective for a variety of reasons in the current context of the multidrug-resistant (MDR) pandemic. Specific algorithms should also... Leggi di più
Pubblicato il 17-11-2019
Fonte: CURRENT OPINION IN INFECTIOUS DISEASE - most viewed articles
Purpose of review Antimicrobial resistance among Gram-negative organisms is a rapidly escalating global challenge. Pharmacologic dose optimization based on pharmacokinetic/pharmacodynamic principles is essential for managing Gram-negative infections. High-risk patient populations may receive nonoptimized antimicrobial dosing because pf physiologic changes in acute illness and/or medical interventions. The purpose of this review... Leggi di più
Pubblicato il 17-11-2019
Fonte: CURRENT OPINION IN INFECTIOUS DISEASE - most viewed articles
NEJM Journal Watch and Physician's First Watch coverage of the meeting... Leggi di più
Pubblicato il 17-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
A medication used typically for diabetes type 2 helps patients with heart failure, including those without diabetes.... Leggi di più
Pubblicato il 17-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By Harlan M. Krumholz, MD, SM
An imaging substudy of GALILEO suggests that oral anticoagulation can reduce the frequency of these findings, but the harm overall outweighs the benefit.... Leggi di più
Pubblicato il 17-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By David J. Cohen, MD, MSc
In the first adequately powered, randomized trial to explore this question, rivaroxaban strikes out.... Leggi di più
Pubblicato il 17-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By David J. Cohen, MD, MSc
A centuries-old anti-inflammatory drug seems to improve cardiovascular outcomes, although the mechanism of the benefit remains uncertain.... Leggi di più
Pubblicato il 17-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By Harlan M. Krumholz, MD, SM
AbstractBackgroundPharyngeal and rectal Neisseriagonorrhoeae and Chlamydiatrachomatis play important roles in infection and antibacterial resistance transmission, but no Food and Drug Administration-cleared assays for detection at these sites existed prior to this study. The objective was to estimate performance of assays to detect those infections in pharyngeal and rectal specimens to... Leggi di più
Pubblicato il 17-11-2019
Fonte: CLINICAL INFECTIOUS DISEASE - open access
AbstractBackgroundThe non-communicable disease (NCD) burden in Kenya is not well characterised, despite estimates needed to identify future health priorities. We aim to quantify current and future NCD burden in Kenya by HIV status.MethodsOriginal systematic reviews (SRs) and meta-analyses of prevalence/incidence of cardiovascular disease (CVD), chronic kidney disease, depression, diabetes, high... Leggi di più
Pubblicato il 17-11-2019
Fonte: CLINICAL INFECTIOUS DISEASE - open access
Pubblicato il 17-11-2019
Fonte: CLINICAL INFECTIOUS DISEASE - advance access
Background: Cases of HIV, while infrequent, have been reported during tenofovir disoproxil fumarate/emtricitabine use as pre-exposure prophylaxis (PrEP). We describe the incidence of HIV and patterns of PrEP use within the Veterans Health Administration (VHA). Methods: We conducted a retrospective cohort study among persons initiating PrEP in the VHA between... Leggi di più
Pubblicato il 16-11-2019
Fonte: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES - most viewed articles
Here's the most clicked-on item we featured from NEJM Group this week, in case you missed it the first time around: Insights on Residency...... Leggi di più
Pubblicato il 16-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
An analysis of mostly low-quality studies of pharmaceutical-grade cannabinoids shows no evidence of benefit but does not acknowledge the wealth of evidence showing harmful effects.... Leggi di più
Pubblicato il 16-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By Peter Roy-Byrne, MD
A disposable duodenoscope performed adequately compared with reusable models in a benchtop test.... Leggi di più
Pubblicato il 16-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By Douglas G. Adler, MD, FACG, AGAF, FASGE
In 2019, the majority of 6th to 12th graders prefer fruit or mint flavors.... Leggi di più
Pubblicato il 16-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By F. Bruder Stapleton, MD
Imaging studies point to altered neural activity in regions linked to inhibitory control and adaptive processing of stimulus salience.... Leggi di più
Pubblicato il 16-11-2019
Fonte: NEJM JOURNAL WATCH - specialty: hiv/aids
By Steven Dubovsky, MD